rs6718526

A SNP in the RBMS1 gene on chromosome 2. Its most notable genotype is C;C: 1.9x risk of type-2 diabetes

Gene
RBMS1
Location
Chr 2160,357,664 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
17%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad1.9x risk of type-2 diabetesTypical · 0.068% of people
  2. C;TBad1.5x riskTypical · 0.029% of people
  3. T;TNot ratednormalTypical · 0.03% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 8 HapMap populations.

  • AverageC;C 68% C;T 29% T;T 3%
  • European ancestry (Utah)C;C 73% C;T 25% T;T 3%
  • Han Chinese (Beijing)C;C 73% C;T 24% T;T 2%
  • Japanese (Tokyo)C;C 80% C;T 18% T;T 2%
  • Yoruba (Nigeria)C;C 73% C;T 25% T;T 2%
  • African ancestry (Southwest US)C;C 80% C;T 20% T;T 0%
  • Gujarati IndianC;C 61% C;T 36% T;T 3%
  • Maasai (Kenya)C;C 52% C;T 43% T;T 5%
  • TuscanC;C 54% C;T 42% T;T 4%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs6718526 has been reported in a large study to be associated with type-2 diabetes. The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.49 (CI 1.05-2.11), and for homozygotes, 1.86 (CI 1.32-2.63).

Source and license

Adapted from rs6718526 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.