rs10830963

A SNP in the MTNR1B gene on chromosome 11. Its most notable genotype is G;G: increased type-2 diabetes risk; higher gestational diabetes risk

Gene
MTNR1B
Location
Chr 1192,975,544 (GRCh38)
Highest magnitude
3.1Important
Tested on
23andMe, AncestryDNA
Minor allele frequency
26%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodnormal risk of Type-2 DiabetesTypical · 0.062% of people
  2. C;GBadincreased type-2 diabetes risk; higher gestational diabetes riskWorth knowing · 2.730% of people
  3. G;GMost notableBadincreased type-2 diabetes risk; higher gestational diabetes riskImportant · 3.18% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageC;C 62% C;G 30% G;G 8%
  • European ancestry (Utah)C;C 45% C;G 51% G;G 5%
  • Han Chinese (Beijing)C;C 33% C;G 56% G;G 12%
  • Japanese (Tokyo)C;C 33% C;G 45% G;G 22%
  • Yoruba (Nigeria)C;C 92% C;G 8% G;G 0%
  • African ancestry (Southwest US)C;C 91% C;G 9% G;G 0%
  • Chinese (Denver)C;C 26% C;G 52% G;G 22%
  • Luhya (Kenya)C;C 99% C;G <1% G;G 0%
  • Mexican ancestry (Los Angeles)C;C 55% C;G 38% G;G 7%
  • Maasai (Kenya)C;C 94% C;G 6% G;G 0%
  • TuscanC;C 56% C;G 36% G;G 8%

Conditions, medicines and genes

Other MTNR1B SNPs

All MTNR1B SNPs

Notes

From SNPedia

Show notes, about 180 words

rs10830963 was associated with an increased risk of type-2 diabetes in our Han Chinese cohort (OR 1.16, 95% CI 1.03-1.31, p = 0.015). As previously described, the risk variant was also associated with increased fasting plasma glucose, showing an increase of 0.068 mmol/l (95% CI 0.036-0.100, p = 4 x 10(-5)) per risk allele rs10830962, rs4753426, and rs10830963 were significantly associated with higher fasting plasma glucose concentrations and reduced OGTT- and IVGTT-induced insulin release. rs3781638 displayed significant association with lower fasting plasma glucose levels and increased OGTT-induced insulin release A study totaling 19,000+ Europeans concluded that rs10830963 had the most influence of any MTNR1B gene SNP on the risk for type-2 diabetes. Specifically, the (G) allele increased the risk of isolated impaired fasting glycemia (OR=1.64, P=5.5x10(-11)) but not isolated impaired glucose tolerance. 900+ patients with gestational diabetes were studied, and the rs10830963(G) SNP was postulated to perhaps be a causal SNP for the condition, with an odds ratio of ~1.3 - 1.4.

Source and license

Adapted from rs10830963 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.