rs1889018

A SNP in the SREBF1 gene on chromosome 17. Its most notable genotype is G;G: normal

Gene
SREBF1
Location
Chr 1717,831,426 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
32%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratednormalTypical · 0.061% of people
  2. A;GNot rated1.12x increased risk for T2DTypical · 0.029% of people
  3. A;ANot rated1.12x increased risk for T2DTypical · 0.010% of people

SNPedia records rs1889018 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 61% A;G 29% A;A 10%
  • European ancestry (Utah)G;G 11% A;G 41% A;A 49%
  • Han Chinese (Beijing)G;G 91% A;G 9% A;A <1%
  • Japanese (Tokyo)G;G 88% A;G 12% A;A <1%
  • Yoruba (Nigeria)G;G 82% A;G 17% A;A <1%
  • African ancestry (Southwest US)G;G 61% A;G 32% A;A 7%
  • Chinese (Denver)G;G 94% A;G 6% A;A <1%
  • Gujarati IndianG;G 58% A;G 37% A;A 5%
  • Luhya (Kenya)G;G 77% A;G 22% A;A <1%
  • Mexican ancestry (Los Angeles)G;G 28% A;G 52% A;A 21%
  • Maasai (Kenya)G;G 65% A;G 35% A;A 0%
  • TuscanG;G 19% A;G 56% A;A 26%

Conditions, medicines and genes

Other SREBF1 SNPs

All SREBF1 SNPs

Notes

From SNPedia

Notes

rs1889018 is one of several SNPs associated with the SREBF1 gene that show a modest association with type-2 diabetes. A study of ~2,000 Caucasian patients (and 10,000+ controls) led to an odds ratio of 1.12 (CI: 1.01-1.24, p=0.04) for the minor (risk) allele, rs1889018(T). This allele was also associated with a surrogate measure of insulin sensitivity (p=0.03).

Source and license

Adapted from rs1889018 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.