rs11868035

A SNP in the SREBF1 gene on chromosome 17. Its most notable genotype is A;A: 1.19x increased risk for T2D

Gene
SREBF1
Location
Chr 1717,811,787 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad1.19x increased risk for T2DTypical · 0.030% of people
  2. A;GBad1.19x increased risk for T2DTypical · 0.038% of people
  3. G;GNot ratednormalTypical · 0.032% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 30% A;G 38% G;G 32%
  • European ancestry (Utah)A;A 8% A;G 40% G;G 52%
  • Han Chinese (Beijing)A;A 69% A;G 27% G;G 4%
  • Japanese (Tokyo)A;A 66% A;G 28% G;G 5%
  • Yoruba (Nigeria)A;A 3% A;G 40% G;G 58%
  • African ancestry (Southwest US)A;A 4% A;G 46% G;G 51%
  • Chinese (Denver)A;A 77% A;G 22% G;G 2%
  • Gujarati IndianA;A 51% A;G 43% G;G 7%
  • Luhya (Kenya)A;A 8% A;G 31% G;G 61%
  • Mexican ancestry (Los Angeles)A;A 17% A;G 53% G;G 29%
  • Maasai (Kenya)A;A 13% A;G 38% G;G 49%
  • TuscanA;A 12% A;G 55% G;G 33%

Conditions, medicines and genes

Other SREBF1 SNPs

All SREBF1 SNPs

Notes

From SNPedia

Notes

rs11868035 is one of several SNPs associated with the SREBF1 gene that show a modest association with type-2 diabetes. A study of ~2,000 Caucasian patients (and 10,000+ controls) led to an odds ratio of 1.19 (CI: 1.07-1.33, p=0.002) for the minor (risk) allele, rs11868035(A), in the orientation as in dbSNP. type-2 diabetes rs2297508(C) and rs11868035(C) This SNP rs11868035 and rs1057217 are associated with increased risk of schizophrenia in German and Scandinavian samples. This SNP and rs6812193 are reported to affect risk of Parkinson's disease. plos Polymorphisms in the gene encoding sterol regulatory element-binding factor-1c are associated with type 2 diabetes.

Source and license

Adapted from rs11868035 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.