Parkinson's disease

96 SNPs linked to Parkinson's disease across 33 genes, 62 with a genotype of magnitude 2 or higher.

Type: Condition
SNPs: 96
Notable: 62Magnitude 2 or higher
Well documented: 31
Genes: 33

Linked SNPs

Every genotype, as shown in 23andMe and AncestryDNA files.

rs45539432PINK1Very important
- C;CnormalGood
- C;TCarrier of an early-onset Parkinson's mutationBad
- T;TParkinson's disease, type 6, early-onset; likelyBad
rs33939927LRRK2Very important
- A;CParkinson's disease mutation, adult-onsetBad
- C;Ccommon in clinvarGood
- C;GParkinson's disease mutation, adult-onsetBad
- C;TParkinson's disease mutation, adult-onsetBad
rs104893877SNCAVery important
- C;TParkinson's disease mutation, adult-onsetBad
- C;Ccommon in clinvarGood
i4000415GBAVery important
- C;CGaucher's diseaseBad
- C;Tcarrier for Gaucher's disease; increased risk for Parkinsons diseaseBad
- T;TnormalGood
rs387907571DNAJC13Very important
- A;Acommon in clinvarGood
- A;GParkinson's disease, possibleBad
rs45478900PINK1Important
- A;G3 fold increase in risk for Parkinson's diseaseBad
- G;Gcommon/normalGood
rs5848GRNImportant
- T;TSomewhat increased (~2 - 3x) dementia riskBad
- C;TSomewhat increased (~2 - 3x) dementia riskBad
- C;Clower dementia riskGood
rs1805008MC1RImportant
- C;Ccommon in clinvarGood
- C;TRed hair carrier, higher risk of melanomaBad
- T;T~7-10x higher likelihood of red hair; higher risk of melanomaBad
rs3892097LOC102723722Important
- T;TCYP2D6 poor metabolizer; many associations related to drug metabolismBad
- C;Textensive metabolizer (usually)Not rated
- C;Cextensive metabolizerGood
rs34637584LRRK2Important
- A;Apossible miscall in Ancestry V2.0 datasets; otherwise, 15 to 30% chance of Parkinson's disease, depending on age, family history, and ethnicityBad
- A;Gpossible miscall in Ancestry V2.0 datasets; otherwise, 15 to 30% chance of Parkinson's disease, depending on age, family history, and ethnicityBad
- G;GnormalGood
rs283413ADH1CWorth knowing
- C;CnormalGood
- A;C3x higher risk for PDBad
- A;A3x higher risk for PDBad
rs34594498LRRK2Worth knowing
- C;Ccommon in clinvarGood
- C;TSlightly (~2x) higher risk of Parkinson's disease mutation, at least in Asians according to some studiesBad
rs199533NSFWorth knowing
- G;GNormal risk of developing Parkinson's DiseaseGood
- A;GSlightly increased risk of developing Parkinson's DiseaseBad
- A;AIncreased risk of developing Parkinson's DiseaseBad
rs356168SNCAWorth knowing
- A;Aslight decrease in risk for Parkinson's diseaseGood
- A;Gslight decrease in risk for Parkinson's diseaseGood
- G;GcommonNot rated
rs622342SLC22A1Worth knowing
- A;ANo summary available.Not rated
- C;Cinfluences dosage for Parkinson's patientsNot rated
rs9652490LINGO1Worth knowing
- A;A~2x increased risk for Parkinson's disease, and, essential tremorBad
- A;GSlightly increased risk of developing Parkinson's DiseaseBad
- G;GNormal risk of developing Parkinson's DiseaseGood
rs10513789MCCC1Minor
- G;G0.64x decreased risk of Parkinson's diseaseGood
- G;T0.8x decreased risk of Parkinson's diseaseGood
- T;TVery common. Normal risk of Parkinson's disease.Not rated
rs356219LOC105377329Minor
- A;AnormalNot rated
- A;G1.3x increased risk for Parkinson's diseaseBad
- G;G1.6x increased risk for Parkinson's diseaseBad
rs6812193FAM47E-STBD1Minor
- C;Cslightly higher risk of developing Parkinson's Disease for caucasiansBad
- C;Tnormal risk of developing Parkinson's DiseaseGood
- T;TSlightly decreased risk of developing Parkinson's DiseaseGood
rs3758549GBF1Minor
- G;Gincreased risk of parkinson's diseaseBad
- A;Gnormal risk of parkinson's diseaseNot rated
- A;Anormal risk of parkinson's diseaseNot rated
rs1800547MAPTMinor
- A;AMAPT H1/H1 diplotypeNot rated
- A;GMAPT H1/H2 (heterozygous) diplotypeNot rated
- G;GMAPT H2/H2 diplotypeGood
rs2230288GBAMinor
- T;THomozygous for E326K variant of GBA geneNot rated
- C;TE326K variant in GBA geneNot rated
- C;Ccommon in clinvarGood
rs287235USP24Typical
- C;GNo summary available.Not rated
rs1559085CASTTypical
- A;ANo summary available.Not rated
rs1799836MAOBTypical
- G;GNo summary available.Not rated
rs1805874CALB1Typical
- A;ANo summary available.Not rated
- A;CNo summary available.Not rated
- C;CNo summary available.Not rated
rs6438552GSK3BTypical
- A;GNo summary available.Not rated
rs6692804GNAI3Typical
- G;GNo summary available.Good
rs11755699SGK1Typical
- T;Tcommon genotypeGood
rs11868035SREBF1Typical
- A;A1.19x increased risk for T2DBad
- A;G1.19x increased risk for T2DBad
- G;GnormalNot rated
rs16941667ALDH2Typical
- C;Ccommon in complete genomicsGood
rs34424986PARK2Very important
- G;Gcommon in clinvarGood
- A;GCarrier of an early-onset Parkinson's mutationBad
- A;AEarly-onset (juvenile) Parkinson's disease likelyBad
rs137853054PARK2Very important
- G;Gcommon in clinvarGood
- C;GCarrier of an early-onset Parkinson's mutationBad
- C;CEarly-onset (juvenile) Parkinson's disease likelyBad
rs137853055PARK2Very important
- G;Gcommon in clinvarGood
- A;GCarrier of an early-onset Parkinson's mutationBad
- A;AEarly-onset (juvenile) Parkinson's disease likelyBad
rs137853056PARK2Very important
- T;TEarly-onset (juvenile) Parkinson's disease likelyBad
- C;TCarrier of an early-onset Parkinson's mutationBad
- C;Ccommon in clinvarGood
rs137853057PARK2Very important
- T;Tcommon in clinvarGood
- A;TCarrier of an early-onset Parkinson's mutationBad
- A;AEarly-onset (juvenile) Parkinson's disease likelyBad
rs137853058PARK2Very important
- T;TEarly-onset (juvenile) Parkinson's disease likelyBad
- C;TCarrier of an early-onset Parkinson's mutationBad
- C;Ccommon in clinvarGood
rs137853059PARK2Very important
- T;TEarly-onset (juvenile) Parkinson's disease likelyBad
- A;TCarrier of an early-onset Parkinson's mutationBad
- A;Acommon in clinvarGood
rs137853060PARK2Very important
- T;Tcommon in clinvarGood
- A;TCarrier of an early-onset Parkinson's mutationBad
- A;AEarly-onset (juvenile) Parkinson's disease likelyBad
rs397514694PARK2Very important
- C;Ccommon in clinvarGood
- A;CCarrier of an early-onset Parkinson's mutationBad
- A;AEarly-onset (juvenile) Parkinson's disease likelyBad
rs397518439PACRGVery important
- C;Ccommon in clinvarGood
- A;CCarrier of an early-onset Parkinson's mutationBad
- A;AEarly-onset (juvenile) Parkinson's disease likelyBad
rs751037529PARK2Very important
- C;Ccommon/normalGood
- C;GCarrier of an early-onset Parkinson's disease mutationBad
- G;GEarly-onset (juvenile) Parkinson's disease likelyBad
rs28940284PINK1Very important
- A;AParkinson's disease, type 6, early-onsetBad
- A;CCarrier of an early-onset Parkinson's mutationBad
- C;Ccommon in complete genomicsGood
rs28940285PINK1Very important
- C;CParkinson's disease, type 6, early-onsetBad
- C;TCarrier of an early-onset Parkinson's mutationBad
- T;Tcommon in complete genomicsGood
rs74315355PINK1Very important
- A;AParkinson's disease, type 6, early-onsetBad
- A;GCarrier of an early-onset Parkinson's mutationBad
- G;Gcommon in clinvarGood
rs74315356PINK1Very important
- A;AParkinson's disease, type 6, early-onsetBad
- A;GCarrier of an early-onset Parkinson's mutationBad
- G;Gcommon in clinvarGood
rs74315357PINK1Very important
- C;Ccommon in clinvarGood
- C;TCarrier of an early-onset Parkinson's mutationBad
- T;TParkinson's disease, type 6, early-onsetBad
rs74315358PINK1Very important
- A;AParkinson's disease, type 6, early-onsetBad
- A;GCarrier of an early-onset Parkinson's mutationBad
- G;Gcommon in clinvarGood
rs74315359PINK1Very important
- C;Ccommon in clinvarGood
- C;TCarrier of an early-onset Parkinson's mutationBad
- T;TParkinson's disease, type 6, early-onsetBad
rs74315360PINK1Very important
- A;AParkinson's disease, type 6, early-onsetBad
- A;CCarrier of an early-onset Parkinson's mutationBad
- C;Ccommon in clinvarGood
rs119451946PINK1Very important
- C;Ccommon in clinvarGood
- C;TCarrier of an early-onset Parkinson's mutationBad
- T;TParkinson's disease, type 6, early-onset; likelyBad
rs730880302PINK1Very important
- -;-common in clinvarGood
- -;TTAGCarrier of an early-onset Parkinson's mutationBad
- TTAG;TTAGParkinson's disease, type 6, early-onsetBad
rs756677845PINK1Very important
- -;-Parkinson's disease, type 6, early-onsetBad
- -;GCarrier of an early-onset Parkinson's mutationBad
- G;Gcommon in clinvarGood
rs28938172PARK7Very important
- C;CParkinson's disease, type 7, early-onsetBad
- C;TCarrier of an early-onset Parkinson's mutationBad
- T;Tcommon in complete genomicsGood
rs74315351PARK7Very important
- A;AParkinson's disease, type 7, early-onsetBad
- A;GCarrier of an early-onset Parkinson's mutationBad
- G;Gcommon in clinvarGood
rs74315352PARK7Very important
- A;Acommon in clinvarGood
- A;CCarrier of an early-onset Parkinson's mutationBad
- C;CParkinson's disease, type 7, early-onsetBad
rs74315353PARK7Very important
- C;CParkinson's disease, type 7, early-onsetBad
- C;GCarrier of an early-onset Parkinson's mutationBad
- G;Gcommon in clinvarGood
rs74315354PARK7Very important
- A;AParkinson's disease, type 7, early-onset (likely)Bad
- A;GCarrier of an early-onset Parkinson's mutation (likely)Bad
- G;Gcommon in clinvarGood
rs137853051PARK7Very important
- G;Gcommon in clinvarGood
- G;TCarrier of an early-onset Parkinson's mutationBad
- T;TParkinson's disease, type 7, early-onsetBad
rs111290936EIF4G1Very important
- C;Ccommon in complete genomicsGood
- C;TLate-onset Parkinson's disease (likely)Bad
- T;TLate-onset Parkinson's disease (likely)Bad
rs112176450EIF4G1Very important
- A;ALate-onset Parkinson's diseaseBad
- A;GLate-onset Parkinson's diseaseBad
- G;Gcommon in complete genomicsGood
rs775129424ACMSDVery important
- A;GPossible Parkinson's disease mutationBad
- G;Gcommon/normalGood
rs34805604LRRK2Very important
- A;Acommon in clinvarGood
- A;GParkinson's disease mutation, adult-onsetBad
rs34995376LRRK2Very important
- A;GParkinson's disease mutation, adult-onsetBad
- G;Gcommon in clinvarGood
rs35801418LRRK2Very important
- A;Acommon in clinvarGood
- A;GParkinson's disease mutation, adult-onsetBad
rs35808389LRRK2Very important
- A;Acommon in clinvarGood
- A;GParkinson's disease mutation, adult-onsetBad
rs35870237LRRK2Very important
- C;TParkinson's disease mutation, adult-onsetBad
- T;Tcommon in clinvarGood
rs74163686LRRK2Very important
- A;Acommon in clinvarGood
- A;CParkinson's disease mutation, adult-onsetBad
rs104893875SNCAVery important
- C;TParkinson's disease mutation, adult-onsetBad
- C;Ccommon in clinvarGood
rs104893878SNCA-AS1Very important
- C;GParkinson's disease mutation, adult-onsetBad
- C;Ccommon in clinvarGood
rs188286943VPS35Very important
- C;Ccommon in clinvarGood
- C;TParkinson's disease mutation, adult-onsetBad
rs281865052LRRK2Very important
- A;Acommon in clinvarGood
- A;GParkinson's disease mutation, adult-onsetBad
rs281865054LRRK2Very important
- G;Gcommon in clinvarGood
- G;TParkinson's disease mutation, adult-onsetBad
rs431905511SNCAVery important
- C;TParkinson's disease mutation, adult-onsetBad
- C;Ccommon in clinvarGood
rs112019125EIF4G1Very important
- G;Gcommon in complete genomicsGood
- G;TPossible late-onset Parkinson's disease variantBad
- T;TPossible late-onset Parkinson's disease variantBad
rs113169049EIF4G1Very important
- A;Acommon in complete genomicsGood
- A;CPossible late-onset Parkinson's disease variantBad
- C;CPossible late-onset Parkinson's disease variantBad
rs113388242EIF4G1Very important
- C;Ccommon in complete genomicsGood
- C;TPossible late-onset Parkinson's disease variantBad
- T;TPossible late-onset Parkinson's disease variantBad

Other SNPs

No notable genotype or detailed notes

Show 19 SNPs

rs356182
rs737280
rs838552
rs873785
rs914722
rs968529
rs1721082
rs1721100
rs3766606
rs4397141
rs7687945
rs7702187
rs7723605
rs9971942
rs11155313
rs11158026
rs16941669
rs33949390
rs34778348

Source and license

Adapted from Parkinson's disease on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.

Parkinson's disease

Linked SNPs

Genes

Related topics

Genosets

Other SNPs

Source and license