rs33939927

A SNP in the LRRK2 gene on chromosome 12. Its most notable genotype is A;C: Parkinson's disease mutation, adult-onset

Gene
LRRK2
Location
Chr 1240,310,434 (GRCh38)
Highest magnitude
6.5Very important
Tested on
23andMe, AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;CMost notableBadParkinson's disease mutation, adult-onsetVery important · 6.5
  2. C;CGoodcommon in clinvarTypical · 0.0
  3. C;GBadParkinson's disease mutation, adult-onsetVery important · 6.5
  4. C;TBadParkinson's disease mutation, adult-onsetVery important · 6.5

On SNPedia: (A;C), (C;C), (C;G), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other LRRK2 SNPs

All LRRK2 SNPs

Notes

From SNPedia

Notes

rs33939927 represents a rare mutation in the LRRK2 gene on chromosome 12. The normal allele is (C); all three possible variants are reported as considered causative for Parkinson's disease. The three variants are also known as c.4321C>A, p.Arg1441Ser; c.4321C>T (p.Arg1441Cys); and c.4321C>G (p.Arg1441Gly). Considered "definitely pathogenic" in the Movement Disorder Society Genetic mutation database (MDSGene) for autosomal dominant Parkinson disease (type 8).

A;C

see Parkinson's disease and LRRK2

C;G

see Parkinson's disease and LRRK2

C;T

see Parkinson's disease and LRRK2

Source and license

Adapted from rs33939927 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.