rs74163686
A SNP in the LRRK2 gene on chromosome 12. Its most notable genotype is A;C: Parkinson's disease mutation, adult-onset
- Gene
- LRRK2
- Location
- Chr 1240,309,225 (GRCh38)
- Highest magnitude
- 6.5Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AGoodcommon in clinvar
- A;CMost notableBadParkinson's disease mutation, adult-onset
On SNPedia: (A;A), (A;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other LRRK2 SNPs
- rs33939927A;CParkinson's disease mutation, adult-onsetVery important
- rs34805604A;GParkinson's disease mutation, adult-onsetVery important
- rs34995376A;GParkinson's disease mutation, adult-onsetVery important
- rs35801418A;GParkinson's disease mutation, adult-onsetVery important
- rs35808389A;GParkinson's disease mutation, adult-onsetVery important
- rs35870237C;TParkinson's disease mutation, adult-onsetVery important
- rs281865052A;GParkinson's disease mutation, adult-onsetVery important
- rs281865054G;TParkinson's disease mutation, adult-onsetVery important
Notes
From SNPedia
Notes
c.4309A>C (p.Asn1437His or N1437H) Considered "definitely pathogenic" in the Movement Disorder Society Genetic mutation database (MDSGene) for autosomal dominant Parkinson disease (type 8)
A;C
see Parkinson's disease and LRRK2
Source and license
Adapted from rs74163686 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.