rs1559085
A SNP in the CAST gene on chromosome 5. Its most notable genotype is A;A.
- Gene
- CAST
- Location
- Chr 596,742,998 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 7%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs1559085 on the minus strand: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 8 HapMap populations.
- AverageA;A 89%
- European ancestry (Utah)A;A 72%
- Han Chinese (Beijing)A;A 100%
- Japanese (Tokyo)A;A 100%
- Yoruba (Nigeria)A;A 100%
- African ancestry (Southwest US)A;A 97%
- Gujarati IndianA;A 87%
- Mexican ancestry (Los Angeles)A;A 85%
- TuscanA;A 73%
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
rs1559085 is a SNP in the calpastatin CAST gene. A significant association (p = 0.0167) between Parkinson's disease and rs1559085 was found in an analysis of the Center for Inherited Disease Research's (CIDR) genome-wide association study in familial PD. Genomewide association study for susceptibility genes contributing to familial Parkinson disease.
Source and license
Adapted from rs1559085 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.