rs112176450

A SNP in the EIF4G1 gene on chromosome 3. Its most notable genotype is A;A: Late-onset Parkinson's disease

Gene
EIF4G1
Location
Chr 3184,327,401 (GRCh38)
Highest magnitude
8.0Very important
Tested on
23andMe, AncestryDNA
Minor allele frequency
<1%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadLate-onset Parkinson's diseaseVery important · 8.0
  2. A;GBadLate-onset Parkinson's diseaseVery important · 8.0
  3. G;GGoodcommon in complete genomicsTypical · 0.0

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other EIF4G1 SNPs

All EIF4G1 SNPs

Notes

From SNPedia

Notes

rs112176450, also known as c.3614G>A, Arg1205His or R1205H, is a SNP in the eukaryotic translation initiation factor 4 gamma, 1 EIF4G1 gene on chromosome 3. A study of several cases of familial Parkinson's disease concluded that rs112176450(A), a very rare allele, is a dominant mutation leading to late-onset disease. Other mutations in the EIF4G1 gene were also found, with varying degrees of certainty regarding their pathogenicity.

Source and license

Adapted from rs112176450 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.