rs113388242

A SNP in the EIF4G1 gene on chromosome 3. Its most notable genotype is C;T: Possible late-onset Parkinson's disease variant

Gene
EIF4G1
Location
Chr 3184,327,376 (GRCh38)
Highest magnitude
5.0Very important
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon in complete genomicsTypical · 0.0
  2. C;TMost notableBadPossible late-onset Parkinson's disease variantVery important · 5.0
  3. T;TBadPossible late-onset Parkinson's disease variantVery important · 5.0

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other EIF4G1 SNPs

All EIF4G1 SNPs

Notes

From SNPedia

Notes

rs113388242, also known as Arg1197Trp or R1197W, is a SNP in the eukaryotic translation initiation factor 4 gamma, 1 EIF4G1 gene on chromosome 3. A study of several cases of familial Parkinson's disease concluded that rs113388242(T), a very rare allele, may be a dominant mutation leading to late-onset disease. Other mutations in the EIF4G1 gene were also found, with varying degrees of certainty regarding their pathogenicity.

Source and license

Adapted from rs113388242 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.