rs111290936

A SNP in the EIF4G1 gene on chromosome 3. Its most notable genotype is C;T: Late-onset Parkinson's disease (likely)

Gene
EIF4G1
Location
Chr 3184,322,089 (GRCh38)
Highest magnitude
8.0Very important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon in complete genomicsTypical · 0.0
  2. C;TMost notableBadLate-onset Parkinson's disease (likely)Very important · 8.0
  3. T;TBadLate-onset Parkinson's disease (likely)Very important · 8.0

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other EIF4G1 SNPs

All EIF4G1 SNPs

Notes

From SNPedia

Notes

rs111290936, also known as c.1505C>T, Ala502Val or A502V, is a SNP in the eukaryotic translation initiation factor 4 gamma, 1 EIF4G1 gene on chromosome 3. A study of several cases of familial Parkinson's disease concluded that rs111290936(T), a very rare allele, is likely to be a dominant mutation leading to late-onset disease. Other mutations in the EIF4G1 gene were also found, with varying degrees of certainty regarding their pathogenicity.

Source and license

Adapted from rs111290936 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.