rs356219

A SNP in the LOC105377329 gene on chromosome 4. Its most notable genotype is G;G: 1.6x increased risk for Parkinson's disease

Gene
LOC105377329
Location
Chr 489,716,450 (GRCh38)
Highest magnitude
1.6Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
49%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratednormalTypical · 0.020% of people
  2. A;GBad1.3x increased risk for Parkinson's diseaseMinor · 1.346% of people
  3. G;GMost notableBad1.6x increased risk for Parkinson's diseaseMinor · 1.634% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 20% A;G 46% G;G 34%
  • European ancestry (Utah)A;A 32% A;G 51% G;G 17%
  • Han Chinese (Beijing)A;A 22% A;G 53% G;G 24%
  • Japanese (Tokyo)A;A 20% A;G 42% G;G 38%
  • Yoruba (Nigeria)A;A 5% A;G 39% G;G 56%

Conditions, medicines and genes

Other LOC105377329 SNPs

All LOC105377329 SNPs

Notes

From SNPedia

Show notes, about 240 words

rs356219, a tagging SNP in the SNCA gene for a Parkinson's disease associated haplotype, predicts the amount of SNCA (alpha-synuclein) mRNA found in post mortem substantia nigra and cerebellum brain tissue. replicates the association of rs356219 with late-onset Parkinson's disease, calculating an odds ratio of 1.3 (CI: 1.13 - 1.5, p=2x10e-4) per rs356219(G) allele among the 1145 patients from northern Spain studied. {{PMID Auto |PMID=21060011 |Title=SNCA Variant Associated With Parkinson Disease and Plasma {alpha}-Synuclein Level |OA=1 }} Linkage disequilibrium patterns and tagSNP transferability among European populations. Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease. Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain. Cerebellar alpha-synuclein levels are decreased in Parkinson's disease and do not correlate with SNCA polymorphisms associated with disease in a Swedish material. Genomewide association study for susceptibility genes contributing to familial Parkinson disease. Genetic susceptibility in Parkinson's disease. Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy. Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues. Independent and joint effects of the MAPT and SNCA genes in Parkinson disease. SNCA polymorphisms, smoking, and sporadic Parkinson's disease in Japanese.

Source and license

Adapted from rs356219 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.