rs356220

A SNP in the LOC105377329 gene on chromosome 4. Its most notable genotype is T;T: increased risk of Parkinson's Disease

Gene
LOC105377329
Location
Chr 489,720,189 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
42%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot ratedNo summary available.Typical · 0.018% of people
  2. T;TMost notableBadincreased risk of Parkinson's DiseaseMinor · 1.534% of people

On SNPedia: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 18% T;T 34%
  • European ancestry (Utah)C;C 35% T;T 15%
  • Han Chinese (Beijing)C;C 24% T;T 24%
  • Japanese (Tokyo)C;C 16% T;T 36%
  • Yoruba (Nigeria)C;C 3% T;T 59%
  • African ancestry (Southwest US)C;C 11% T;T 47%
  • Chinese (Denver)C;C 16% T;T 29%
  • Gujarati IndianC;C 32% T;T 12%
  • Luhya (Kenya)C;C 7% T;T 52%
  • Mexican ancestry (Los Angeles)C;C 14% T;T 26%
  • Maasai (Kenya)C;C 5% T;T 51%
  • TuscanC;C 38% T;T 19%

Other LOC105377329 SNPs

All LOC105377329 SNPs

Source and license

Adapted from rs356220 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.