rs775129424

A SNP in the ACMSD gene on chromosome 2. Its most notable genotype is A;G: Possible Parkinson's disease mutation

Gene
ACMSD
Location
Chr 2134,898,383 (GRCh38)
Highest magnitude
7.0Very important
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;GMost notableBadPossible Parkinson's disease mutationVery important · 7.0
  2. G;GGoodcommon/normalTypical · 0.0

On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other ACMSD SNPs

All ACMSD SNPs

Notes

From SNPedia

Notes

A mutation in the ACMSD gene, rs775129424(A), also known as p.Glu298Lys or E298K, is considered to be the likely cause of Parkinson's disease in a male diagnosed at age 74. It appeared to be a sporadic (de novo) germline mutation, acting in a dominant manner.

A;G

see discussion at rs775129424

Source and license

Adapted from rs775129424 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.