rs104893878

A SNP in the SNCA-AS1 gene on chromosome 4. Its most notable genotype is C;G: Parkinson's disease mutation, adult-onset

Gene
SNCA-AS1
Location
Chr 489,835,580 (GRCh38)
Highest magnitude
6.5Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;GMost notableBadParkinson's disease mutation, adult-onsetVery important · 6.5
  2. C;CGoodcommon in clinvarTypical · 0.0

SNPedia records rs104893878 on the minus strand: (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

c.88G>C (p.Ala30Pro or A30P) Considered "probably pathogenic" in the Movement Disorder Society Genetic mutation database (MDSGene) for autosomal dominant Parkinson disease 23andMe calls this i6018768

C;G

see Parkinson's disease and SNCA

Source and license

Adapted from rs104893878 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.