rs188286943

A SNP in the VPS35 gene on chromosome 16. Its most notable genotype is C;T: Parkinson's disease mutation, adult-onset

Gene
VPS35
Location
Chr 1646,662,452 (GRCh38)
Highest magnitude
6.5Very important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon in clinvarTypical · 0.0
  2. C;TMost notableBadParkinson's disease mutation, adult-onsetVery important · 6.5

On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other VPS35 SNPs

All VPS35 SNPs

Notes

From SNPedia

Notes

aka c.1858G>A, p.Asp620Asn, D620N Lengthy discussion on OMIM at 601501.0001 Considered "definitely pathogenic" in the Movement Disorder Society Genetic mutation database (MDSGene) for autosomal dominant Parkinson disease.

C;T

see Parkinson's disease and rs188286943

Source and license

Adapted from rs188286943 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.