rs6812193

A SNP in the FAM47E-STBD1 gene on chromosome 4. Its most notable genotype is T;T: Slightly decreased risk of developing Parkinson's Disease

Gene
FAM47E-STBD1
Location
Chr 476,277,833 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
30%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CBadslightly higher risk of developing Parkinson's Disease for caucasiansMinor · 1.149% of people
  2. C;TGoodnormal risk of developing Parkinson's DiseaseMinor · 1.040% of people
  3. T;TMost notableGoodSlightly decreased risk of developing Parkinson's DiseaseMinor · 1.511% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 49% C;T 40% T;T 11%
  • European ancestry (Utah)C;C 35% C;T 51% T;T 14%
  • Han Chinese (Beijing)C;C 80% C;T 18% T;T 2%
  • Japanese (Tokyo)C;C 84% C;T 14% T;T 2%
  • Yoruba (Nigeria)C;C 29% C;T 55% T;T 16%
  • African ancestry (Southwest US)C;C 26% C;T 53% T;T 21%
  • Chinese (Denver)C;C 84% C;T 15% T;T 2%
  • Gujarati IndianC;C 51% C;T 46% T;T 4%
  • Luhya (Kenya)C;C 29% C;T 48% T;T 23%
  • Mexican ancestry (Los Angeles)C;C 64% C;T 29% T;T 7%
  • Maasai (Kenya)C;C 28% C;T 53% T;T 19%
  • TuscanC;C 30% C;T 54% T;T 16%

Conditions, medicines and genes

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

People with two copies of the T allele at rs6812193 appear to have a slightly lower risk of Parkinson's disease. The same researchers identified another risk allele for Parkinson's disease at rs11868035. plos

C;C

but it has failed to reproduce in Greeks and Chinese populations. If there is an effect is is very small.

T;T

As reported in European populations, but with failure to reproduce in Greek or Chinese populations.

Source and license

Adapted from rs6812193 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.