rs356168

A SNP in the SNCA gene on chromosome 4. Its most notable genotype is A;A: slight decrease in risk for Parkinson's disease

Gene
SNCA
Location
Chr 489,753,280 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodslight decrease in risk for Parkinson's diseaseWorth knowing · 2.014% of people
  2. A;GGoodslight decrease in risk for Parkinson's diseaseWorth knowing · 2.043% of people
  3. G;GNot ratedcommonTypical · 0.043% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 14% A;G 43% G;G 43%
  • European ancestry (Utah)A;A 27% A;G 51% G;G 21%
  • Han Chinese (Beijing)A;A 19% A;G 50% G;G 31%
  • Japanese (Tokyo)A;A 12% A;G 46% G;G 42%
  • Yoruba (Nigeria)A;A 1% A;G 23% G;G 76%
  • African ancestry (Southwest US)A;A 5% A;G 26% G;G 68%
  • Chinese (Denver)A;A 15% A;G 52% G;G 33%
  • Gujarati IndianA;A 19% A;G 57% G;G 24%
  • Luhya (Kenya)A;A 3% A;G 39% G;G 58%
  • Mexican ancestry (Los Angeles)A;A 14% A;G 55% G;G 31%
  • Maasai (Kenya)A;A 5% A;G 34% G;G 62%
  • TuscanA;A 31% A;G 44% G;G 25%

Conditions, medicines and genes

Other SNCA SNPs

All SNCA SNPs

Notes

From SNPedia

Notes

rs356168 represents a common SNP in an untranslated region of the SNCA gene on chromosome 4. The rs356168(A) allele yields a slightly reduced risk for Parkinson's disease compared to the more common (G) allele. An in vitro study of the effect of the rs356168(G) allele concludes it leads to increased transcription of the corresponding SNCA allele, which the authors feel is a credible explanation for the slight increase in risk for Parkinson's.

A;A

see discussion at rs356168

A;G

see discussion at rs356168

Source and license

Adapted from rs356168 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.