rs356165
A SNP in the SNCA gene on chromosome 4. Its most notable genotype is G;G: common in clinvar
- Gene
- SNCA
- Location
- Chr 489,725,735 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
- Minor allele frequency
- 49%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageG;G 35%
- European ancestry (Utah)G;G 19%
- Han Chinese (Beijing)G;G 27%
- Japanese (Tokyo)G;G 37%
- Yoruba (Nigeria)G;G 57%
Related
Other SNCA SNPs
- rs104893875C;TParkinson's disease mutation, adult-onsetVery important
- rs104893877C;TParkinson's disease mutation, adult-onsetVery important
- rs431905511C;TParkinson's disease mutation, adult-onsetVery important
- rs356168A;Aslight decrease in risk for Parkinson's diseaseWorth knowing
- rs2736990G;GSlightly increased risk of developing Parkinson's DiseaseWorth knowing
- rs3775442C;Ccommon genotypeTypical
Notes
From SNPedia
Show notes, about 140 words
rs356165 is a SNP in the 3' UTR of the alpha-synuclein SNCA gene. It has been associated in some studies, and not others, with Parkinson's disease. A study of 330 Chinese with Parkinson's found no association with rs356165 and risk for Parkinson's. Linkage disequilibrium patterns and tagSNP transferability among European populations. Familial genes in sporadic disease: common variants of alpha-synuclein gene associate with Parkinson's disease. alpha-Synuclein and Parkinson disease susceptibility. Genetic susceptibility in Parkinson's disease. Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy. Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population. An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology.
Source and license
Adapted from rs356165 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.