rs104893877
A SNP in the SNCA gene on chromosome 4. Its most notable genotype is C;T: Parkinson's disease mutation, adult-onset
- Gene
- SNCA
- Location
- Chr 489,828,149 (GRCh38)
- Highest magnitude
- 6.5Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs104893877 on the minus strand: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other SNCA SNPs
- rs104893875C;TParkinson's disease mutation, adult-onsetVery important
- rs431905511C;TParkinson's disease mutation, adult-onsetVery important
- rs356168A;Aslight decrease in risk for Parkinson's diseaseWorth knowing
- rs2736990G;GSlightly increased risk of developing Parkinson's DiseaseWorth knowing
- rs356165G;Gcommon in clinvarTypical
- rs3775442C;Ccommon genotypeTypical
Notes
From SNPedia
Show notes, about 130 words
aka c.157G>A, p.Ala53Thr or A53T 23andMe name: i6018770 In addition to this variant's association with Parkinson's disease in general, possibly early-onset type, a 2018 publication based on the use of human stem cells reported that exposure of those cells to certain pesticides (paraquat and maneb) at relatively low levels impaired the function of dopamine-producing neurons if (and only if) they carried the A53T variant. This supports previous conclusions that pesticides increase the risk of Parkinson's disease in genetically predisposed people. Considered "definitely pathogenic" in the Movement Disorder Society Genetic mutation database (MDSGene) for autosomal dominant Parkinson disease. See also OMIM 163890.0001
C;T
see Parkinson's disease and SNCA
Source and license
Adapted from rs104893877 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.