rs431905511
A SNP in the SNCA gene on chromosome 4. Its most notable genotype is C;T: Parkinson's disease mutation, adult-onset
- Gene
- SNCA
- Location
- Chr 489,828,154 (GRCh38)
- Highest magnitude
- 6.5Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- C;TMost notableBadParkinson's disease mutation, adult-onset
- C;CGoodcommon in clinvar
SNPedia records rs431905511 on the minus strand: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other SNCA SNPs
- rs104893875C;TParkinson's disease mutation, adult-onsetVery important
- rs104893877C;TParkinson's disease mutation, adult-onsetVery important
- rs356168A;Aslight decrease in risk for Parkinson's diseaseWorth knowing
- rs2736990G;GSlightly increased risk of developing Parkinson's DiseaseWorth knowing
- rs356165G;Gcommon in clinvarTypical
- rs3775442C;Ccommon genotypeTypical
Notes
From SNPedia
Notes
c.152G>A (p.Gly51Asp or G51D) Considered "definitely pathogenic" in the Movement Disorder Society Genetic mutation database (MDSGene) for autosomal dominant Parkinson disease See also OMIM 163890.0006
C;T
see Parkinson's disease and SNCA
Source and license
Adapted from rs431905511 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.