rs1800547

A SNP in the MAPT gene on chromosome 17. Its most notable genotype is A;A: MAPT H1/H1 diplotype

Gene
MAPT
Location
Chr 1745,974,480 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
12%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedMAPT H1/H1 diplotypeMinor · 1.080% of people
  2. A;GNot ratedMAPT H1/H2 (heterozygous) diplotypeMinor · 1.017% of people
  3. G;GGoodMAPT H2/H2 diplotypeMinor · 1.03% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 9 HapMap populations.

  • AverageA;A 80% A;G 17% G;G 3%
  • European ancestry (Utah)A;A 59% A;G 40% G;G <1%
  • Han Chinese (Beijing)A;A 100% A;G 0% G;G 0%
  • Japanese (Tokyo)A;A 99% A;G <1% G;G 0%
  • Yoruba (Nigeria)A;A 99% A;G 1% G;G 0%
  • African ancestry (Southwest US)A;A 81% A;G 18% G;G 2%
  • Gujarati IndianA;A 82% A;G 17% G;G 1%
  • Mexican ancestry (Los Angeles)A;A 71% A;G 22% G;G 7%
  • Maasai (Kenya)A;A 89% A;G 9% G;G 3%
  • TuscanA;A 42% A;G 44% G;G 14%

Conditions, medicines and genes

Other MAPT SNPs

All MAPT SNPs

Notes

From SNPedia

Notes

replicates the association between rs1800547 and late-onset Parkinson's disease, calculating an odds ratio of 0.77 (CI: 0.66 - 0.88, p=3x10e-4) for the rarer rs1800547(G) allele among 1445 patients from northern Spain. significantly associated with parkinson's disease

Source and license

Adapted from rs1800547 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.