rs63750424
A SNP in the MAPT gene on chromosome 17. Its most notable genotype is C;T: Frontotemporal dementia (predicted)
- Gene
- MAPT
- Location
- Chr 1746,024,061 (GRCh38)
- Highest magnitude
- 7.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon in clinvar
- C;TMost notableBadFrontotemporal dementia (predicted)
On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other MAPT SNPs
- rs8070723G;G~0.05x (thus greatly) reduced risk for developing progressive supranuclear palsyWorth knowing
- rs143624519A;Asome increase in risk for neurodegenerative disordersWorth knowing
- rs1800547A;AMAPT H1/H1 diplotypeMinor
- rs7521A;Acommon in clinvarTypical
- rs9468T;Tcommon in clinvarTypical
- rs242557A;GnormalTypical
- rs1052553A;Acommon in clinvarTypical
- rs1864325C;CNo summary available.Typical
Notes
From SNPedia
Notes
aka c.1216C>T (p.Arg406Trp or R406W) The R406W mutation in the MAPT gene, rs63750424(T), is considered to be inherited in a dominant manner and to lead to frontotemporal dementia, in many ways akin to some forms of Alzheimer's disease.OMIM
C;T
see text and links via main rs-page
Source and license
Adapted from rs63750424 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.