rs8070723

A SNP in the MAPT gene on chromosome 17. Its most notable genotype is G;G: ~0.05x (thus greatly) reduced risk for developing progressive supranuclear palsy

Gene
MAPT
Location
Chr 1746,003,698 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
15%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratedNo summary available.Typical · 0.074% of people
  2. A;GGood0.18x reduced risk of developing progressive supranuclear palsyWorth knowing · 2.023% of people
  3. G;GMost notableGood~0.05x (thus greatly) reduced risk for developing progressive supranuclear palsyWorth knowing · 2.53% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageA;A 74% A;G 23% G;G 3%
  • European ancestry (Utah)A;A 59% A;G 40% G;G <1%
  • Han Chinese (Beijing)A;A 100% A;G 0% G;G 0%
  • Japanese (Tokyo)A;A 99% A;G <1% G;G 0%
  • Yoruba (Nigeria)A;A 76% A;G 24% G;G <1%
  • African ancestry (Southwest US)A;A 56% A;G 42% G;G 2%
  • Gujarati IndianA;A 82% A;G 17% G;G 1%
  • Luhya (Kenya)A;A 77% A;G 22% G;G <1%
  • Mexican ancestry (Los Angeles)A;A 74% A;G 18% G;G 9%
  • Maasai (Kenya)A;A 76% A;G 21% G;G 4%
  • TuscanA;A 42% A;G 44% G;G 14%

Conditions, medicines and genes

Other MAPT SNPs

All MAPT SNPs

Notes

From SNPedia

Notes

Each copy of the G version of rs8070723 was associated with about 5.5 times lower odds of progressive supranuclear palsy. The researchers identified smaller effects at rs1411478, rs7571971 and rs1768208. 23andMe blog Genomewide association study for susceptibility genes contributing to familial Parkinson disease. Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.

Source and license

Adapted from rs8070723 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.