rs1864325
A SNP in the MAPT gene on chromosome 17. Its most notable genotype is C;C.
- Gene
- MAPT
- Location
- Chr 1745,900,461 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 12%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 9 HapMap populations.
- AverageC;C 80%
- European ancestry (Utah)C;C 59%
- Han Chinese (Beijing)C;C 100%
- Japanese (Tokyo)C;C 99%
- Yoruba (Nigeria)C;C 99%
- African ancestry (Southwest US)C;C 83%
- Gujarati IndianC;C 82%
- Mexican ancestry (Los Angeles)C;C 70%
- Maasai (Kenya)C;C 89%
- TuscanC;C 42%
Related
Other MAPT SNPs
- rs63750424C;TFrontotemporal dementia (predicted)Very important
- rs8070723G;G~0.05x (thus greatly) reduced risk for developing progressive supranuclear palsyWorth knowing
- rs143624519A;Asome increase in risk for neurodegenerative disordersWorth knowing
- rs1800547A;AMAPT H1/H1 diplotypeMinor
- rs7521A;Acommon in clinvarTypical
- rs9468T;Tcommon in clinvarTypical
- rs242557A;GnormalTypical
- rs1052553A;Acommon in clinvarTypical
Notes
From SNPedia
Notes
blog rs1864325 is a predictor for the two sequences. A C at the SNP corresponds to the typical African haplotype, while a T at the SNP corresponds to the mysterious European haplotype.
Source and license
Adapted from rs1864325 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.