rs143624519
A SNP in the MAPT gene on chromosome 17. Its most notable genotype is A;A: some increase in risk for neurodegenerative disorders
- Gene
- MAPT
- Location
- Chr 1745,991,484 (GRCh38)
- Highest magnitude
- 2.5Worth knowing
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadsome increase in risk for neurodegenerative disorders
- A;GBadslight? increase in risk for neurodegenerative disorders
- G;GGoodcommon/normal
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other MAPT SNPs
- rs63750424C;TFrontotemporal dementia (predicted)Very important
- rs8070723G;G~0.05x (thus greatly) reduced risk for developing progressive supranuclear palsyWorth knowing
- rs1800547A;AMAPT H1/H1 diplotypeMinor
- rs7521A;Acommon in clinvarTypical
- rs9468T;Tcommon in clinvarTypical
- rs242557A;GnormalTypical
- rs1052553A;Acommon in clinvarTypical
- rs1864325C;CNo summary available.Typical
Notes
From SNPedia
Show notes, about 130 words
rs143624519, also known as c.454G>A, p.Ala152Thr and A152T, represents a relatively rare variant in the MAPT gene on chromosome 17. This variant may also be known as tau-A152. Publications have linked the rare rs143624519(A) allele to somewhat increased risk for neurodegenerative diseases. As stated here on AlzForum, "Unlike the majority of pathogenic mutations in MAPT, the A152T variant does not appear to cause autosomal-dominant disease. Instead, it acts as a risk modifier and increases susceptibility to several neurodegenerative conditions, including Alzheimer's disease, frontotemporal dementia, and dementia with Lewy bodies". The odds ratios vary between conditions - and publications - but range between about 2 to 6.
A;A
see discussion at rs143624519
A;G
see discussion at rs143624519
Source and license
Adapted from rs143624519 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.