rs7521
A SNP in the MAPT gene on chromosome 17. Its most notable genotype is A;A: common in clinvar
- Gene
- MAPT
- Location
- Chr 1746,028,029 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 32%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 13%
- European ancestry (Utah)A;A 19%
- Han Chinese (Beijing)A;A 0%
- Japanese (Tokyo)A;A <1%
- Yoruba (Nigeria)A;A 18%
- African ancestry (Southwest US)A;A 18%
- Chinese (Denver)A;A 2%
- Gujarati IndianA;A 34%
- Luhya (Kenya)A;A 18%
- Mexican ancestry (Los Angeles)A;A 7%
- Maasai (Kenya)A;A 17%
- TuscanA;A 15%
Related
Other MAPT SNPs
- rs63750424C;TFrontotemporal dementia (predicted)Very important
- rs8070723G;G~0.05x (thus greatly) reduced risk for developing progressive supranuclear palsyWorth knowing
- rs143624519A;Asome increase in risk for neurodegenerative disordersWorth knowing
- rs1800547A;AMAPT H1/H1 diplotypeMinor
- rs9468T;Tcommon in clinvarTypical
- rs242557A;GnormalTypical
- rs1052553A;Acommon in clinvarTypical
- rs1864325C;CNo summary available.Typical
Source and license
Adapted from rs7521 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.