rs1052553
A SNP in the MAPT gene on chromosome 17. Its most notable genotype is A;A: common in clinvar
- Gene
- MAPT
- Location
- Chr 1745,996,523 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 12%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 9 HapMap populations.
- AverageA;A 80%
- European ancestry (Utah)A;A 59%
- Han Chinese (Beijing)A;A 100%
- Japanese (Tokyo)A;A 99%
- Yoruba (Nigeria)A;A 98%
- African ancestry (Southwest US)A;A 81%
- Gujarati IndianA;A 82%
- Mexican ancestry (Los Angeles)A;A 71%
- Maasai (Kenya)A;A 88%
- TuscanA;A 42%
Related
Other MAPT SNPs
- rs63750424C;TFrontotemporal dementia (predicted)Very important
- rs8070723G;G~0.05x (thus greatly) reduced risk for developing progressive supranuclear palsyWorth knowing
- rs143624519A;Asome increase in risk for neurodegenerative disordersWorth knowing
- rs1800547A;AMAPT H1/H1 diplotypeMinor
- rs7521A;Acommon in clinvarTypical
- rs9468T;Tcommon in clinvarTypical
- rs242557A;GnormalTypical
- rs1864325C;CNo summary available.Typical
Notes
From SNPedia
Notes
Haplotypes and gene expression implicate the MAPT region for Parkinson disease: the GenePD Study. The distribution and most recent common ancestor of the 17q21 inversion in humans. Independent and joint effects of the MAPT and SNCA genes in Parkinson disease.
Source and license
Adapted from rs1052553 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.