rs1805874

A SNP in the CALB1 gene on chromosome 8. Its most notable genotype is A;A.

Gene
CALB1
Location
Chr 890,069,834 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
44%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedNo summary available.Typical · 0.023% of people
  2. A;CNot ratedNo summary available.Typical · 0.042% of people
  3. C;CNot ratedNo summary available.Typical · 0.036% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 23% A;C 42% C;C 36%
  • European ancestry (Utah)A;A 10% A;C 41% C;C 50%
  • Han Chinese (Beijing)A;A 47% A;C 47% C;C 6%
  • Japanese (Tokyo)A;A 58% A;C 35% C;C 7%
  • Yoruba (Nigeria)A;A 4% A;C 27% C;C 69%
  • African ancestry (Southwest US)A;A 2% A;C 51% C;C 47%
  • Chinese (Denver)A;A 35% A;C 52% C;C 13%
  • Gujarati IndianA;A 26% A;C 46% C;C 29%
  • Luhya (Kenya)A;A 4% A;C 45% C;C 52%
  • Mexican ancestry (Los Angeles)A;A 38% A;C 35% C;C 28%
  • Maasai (Kenya)A;A 15% A;C 39% C;C 46%
  • TuscanA;A 9% A;C 42% C;C 49%

Conditions, medicines and genes

Notes

From SNPedia

Notes

Parkinson's disease (PD). rs1805874 showed significance in both analyses (P = 7.1 x 10(-5); recessive model). However, a more recent study of 4 Caucasian populations (comprising 1500+ patients) found no association between rs1805874 and Parkinson's disease, at least for these populations.

Source and license

Adapted from rs1805874 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.