rs199533

A SNP in the NSF gene on chromosome 17. Its most notable genotype is A;A: Increased risk of developing Parkinson's Disease

Gene
NSF
Location
Chr 1746,751,565 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
11%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodNormal risk of developing Parkinson's DiseaseMinor · 1.085% of people
  2. A;GBadSlightly increased risk of developing Parkinson's DiseaseMinor · 1.513% of people
  3. A;AMost notableBadIncreased risk of developing Parkinson's DiseaseWorth knowing · 2.02% of people

SNPedia records rs199533 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageG;G 85% A;G 13% A;A 2%
  • European ancestry (Utah)G;G 62% A;G 37% A;A <1%
  • Han Chinese (Beijing)G;G 100% A;G 0% A;A 0%
  • Japanese (Tokyo)G;G 99% A;G <1% A;A 0%
  • Yoruba (Nigeria)G;G 100% A;G 0% A;A 0%
  • African ancestry (Southwest US)G;G 84% A;G 16% A;A 0%
  • Gujarati IndianG;G 84% A;G 14% A;A 2%
  • Luhya (Kenya)G;G 99% A;G <1% A;A 0%
  • Mexican ancestry (Los Angeles)G;G 74% A;G 21% A;A 5%
  • Maasai (Kenya)G;G 93% A;G 6% A;A 1%
  • TuscanG;G 50% A;G 38% A;A 12%

Conditions, medicines and genes

Notes

From SNPedia

Notes

A;A

The (T;T) genotype at this position suggests an increased risk of Parkinson's Disease. The homozygote form (T;T) is more common. The other SNP that definitely relates to NSF is rs183211. rs199533 along with rs2736990 and rs393152 were cited in this gwas study regarding the risk of underlying Parkinson’s disease. .

References

Source and license

Adapted from rs199533 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.