rs28940285
A SNP in the PINK1 gene on chromosome 1. Its most notable genotype is C;C: Parkinson's disease, type 6, early-onset
- Gene
- PINK1
- Location
- Chr 120,645,640 (GRCh38)
- Highest magnitude
- 8.9Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableBadParkinson's disease, type 6, early-onset
- C;TBadCarrier of an early-onset Parkinson's mutation
- T;TGoodcommon in complete genomics
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other PINK1 SNPs
- rs28940284A;AParkinson's disease, type 6, early-onsetVery important
- rs45539432T;TParkinson's disease, type 6, early-onset; likelyVery important
- rs74315355A;AParkinson's disease, type 6, early-onsetVery important
- rs74315356A;AParkinson's disease, type 6, early-onsetVery important
- rs74315357T;TParkinson's disease, type 6, early-onsetVery important
- rs74315358A;AParkinson's disease, type 6, early-onsetVery important
- rs74315359T;TParkinson's disease, type 6, early-onsetVery important
- rs74315360A;AParkinson's disease, type 6, early-onsetVery important
Notes
From SNPedia
Notes
c.1040T>C (p.Leu347Pro or L347P) Considered "definitely pathogenic" in the Movement Disorder Society Genetic mutation database (MDSGene) for autosomal recessive, early-onset Parkinson disease (type 6) See also OMIM 608309.0005 23andMe calls this i3003043
C;C
see Parkinson's disease and PINK1
C;T
see Parkinson's disease and PINK1
Source and license
Adapted from rs28940285 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.