rs10513789

A SNP in the MCCC1 gene on chromosome 3. Its most notable genotype is G;G: 0.64x decreased risk of Parkinson's disease

Gene
MCCC1
Location
Chr 3183,042,285 (GRCh38)
Highest magnitude
1.8Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
33%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableGood0.64x decreased risk of Parkinson's diseaseMinor · 1.812% of people
  2. G;TGood0.8x decreased risk of Parkinson's diseaseMinor · 1.441% of people
  3. T;TNot ratedVery common. Normal risk of Parkinson's disease.Minor · 1.347% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 12% G;T 41% T;T 47%
  • European ancestry (Utah)G;G 4% G;T 40% T;T 56%
  • Han Chinese (Beijing)G;G 28% G;T 57% T;T 16%
  • Japanese (Tokyo)G;G 21% G;T 62% T;T 17%
  • Yoruba (Nigeria)G;G 5% G;T 26% T;T 69%
  • African ancestry (Southwest US)G;G 4% G;T 32% T;T 64%
  • Chinese (Denver)G;G 26% G;T 59% T;T 16%
  • Gujarati IndianG;G 19% G;T 42% T;T 39%
  • Luhya (Kenya)G;G 6% G;T 21% T;T 74%
  • Mexican ancestry (Los Angeles)G;G 14% G;T 45% T;T 41%
  • Maasai (Kenya)G;G 5% G;T 37% T;T 59%
  • TuscanG;G 4% G;T 32% T;T 64%

Conditions, medicines and genes

Other MCCC1 SNPs

All MCCC1 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

23andMe reports that the G allele of rs10513789 is associated with 0.8 times lower odds of Parkinson's disease. 23andMe has a patent covering this snp. http://blog.23andme.com/2012/05/28/announcing-23andmes-first-patent/ See also gs249 and gs248

T;T

Approximately 55% of non-asian people have this genotype which is associated with slightly higher risk of Parkinson's disease when compared to genotype (G;G). It is notable because it is the first SNP patented by 23andMe rs10513789(T) increased risk of developing Parkinson's Disease GenomicsLawReport

Source and license

Adapted from rs10513789 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.