rs9652490

A SNP in the LINGO1 gene on chromosome 15. Its most notable genotype is A;A: ~2x increased risk for Parkinson's disease, and, essential tremor

Gene
LINGO1
Location
Chr 1577,671,545 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
28%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad~2x increased risk for Parkinson's disease, and, essential tremorWorth knowing · 2.052% of people
  2. A;GBadSlightly increased risk of developing Parkinson's DiseaseMinor · 1.537% of people
  3. G;GGoodNormal risk of developing Parkinson's DiseaseMinor · 1.011% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 52% A;G 37% G;G 11%
  • European ancestry (Utah)A;A 67% A;G 26% G;G 7%
  • Han Chinese (Beijing)A;A 54% A;G 34% G;G 12%
  • Japanese (Tokyo)A;A 46% A;G 48% G;G 6%
  • Yoruba (Nigeria)A;A 24% A;G 46% G;G 30%
  • African ancestry (Southwest US)A;A 35% A;G 47% G;G 18%
  • Chinese (Denver)A;A 65% A;G 33% G;G 2%
  • Gujarati IndianA;A 66% A;G 30% G;G 4%
  • Luhya (Kenya)A;A 37% A;G 39% G;G 25%
  • Mexican ancestry (Los Angeles)A;A 79% A;G 19% G;G 2%
  • Maasai (Kenya)A;A 39% A;G 48% G;G 13%
  • TuscanA;A 62% A;G 34% G;G 4%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 180 words

rs9652490 is a SNP in the LINGO1 gene. Note: it is unclear why one set of authors report the risk allele for essential tremors to be (G), while the others just as clearly report the risk allele to be (A). A follow-up case-control study replicated the original association of rs9652490(A;A) to an ~2x increased risk for Parkinson's disease, but also found the same risk for essential tremor (ET), thus linking the two diseases. The ET study was based on ~300 patients. 23andMe blog "In a combined analysis of 752 subjects with essential tremor from Iceland, Austria, Germany and the United States and 15,797 controls, Stefansson et al found that the G version of rs9652490 in the LINGO1 gene is associated with increased odds of the condition. Carrying one G increases the odds of essential tremor by 1.55 times compared to two As. The approximately 5% of the population with European ancestry with two Gs has 2.40 times increased odds." Finds no evidence that rs9652490 is associated with Parkinson's disease in a Chinese population, or, based on a meta-analysis.

Source and license

Adapted from rs9652490 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.