rs34594498
A SNP in the LRRK2 gene on chromosome 12. Its most notable genotype is C;T: Slightly (~2x) higher risk of Parkinson's disease mutation, at least in Asians according to some studies
- Gene
- LRRK2
- Location
- Chr 1240,252,984 (GRCh38)
- Highest magnitude
- 2.5Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- <1%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon in clinvar
- C;TMost notableBadSlightly (~2x) higher risk of Parkinson's disease mutation, at least in Asians according to some studies
On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other LRRK2 SNPs
- rs33939927A;CParkinson's disease mutation, adult-onsetVery important
- rs34805604A;GParkinson's disease mutation, adult-onsetVery important
- rs34995376A;GParkinson's disease mutation, adult-onsetVery important
- rs35801418A;GParkinson's disease mutation, adult-onsetVery important
- rs35808389A;GParkinson's disease mutation, adult-onsetVery important
- rs35870237C;TParkinson's disease mutation, adult-onsetVery important
- rs74163686A;CParkinson's disease mutation, adult-onsetVery important
- rs281865052A;GParkinson's disease mutation, adult-onsetVery important
Notes
From SNPedia
Show notes, about 160 words
rs34594498, also known as c.1256C>T, p.Ala419Val and A419V, represents a variant in the LRRK2 gene on chromosome 12. The minor allele of this variant has been reported in some studies - and not others - to increase risk (by about 2x) for Parkinson's disease, primarily in studies of Asians. Some of the studies confirming or refuting this variant's role include: Reporting an association: * 2015 study reports a ~2x higher risk for PD in Chinese patients and based on meta-analysis; * 2011 study reports a ~2x higher risk for PD in Asian patients (but not Caucasians) Finding no association: * 2013 study of ~400 Chinese, Malays and Indians finds no association * 2012 study of ~600 Taiwenese PD patients reported no association * 2012 study of ~1,500 Chinese PD patients reported no association Note that this 2006 study concluded that Ala419Val was a "disease-unrelated polymorphism".
C;T
see discussion of conflicting results on main rs-page
Source and license
Adapted from rs34594498 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.