rs2297508

A SNP in the SREBF1 gene on chromosome 17. Its most notable genotype is G;G: normal

Gene
SREBF1
Location
Chr 1717,812,003 (GRCh38)
Highest magnitude
0.0Typical
Tested on
Not on consumer chips
Minor allele frequency
46%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratednormalTypical · 0.030% of people
  2. C;GNot rated1.08x increased risk for T2DTypical · 0.030% of people
  3. C;CNot rated1.08x increased risk for T2DTypical · 0.040% of people

SNPedia records rs2297508 on the minus strand: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 30% C;G 30% C;C 40%
  • European ancestry (Utah)G;G 59% C;G 32% C;C 9%
  • Han Chinese (Beijing)G;G 7% C;G 22% C;C 71%
  • Japanese (Tokyo)G;G 0% C;G 32% C;C 68%
  • Yoruba (Nigeria)G;G 54% C;G 33% C;C 13%

Conditions, medicines and genes

Other SREBF1 SNPs

All SREBF1 SNPs

Notes

From SNPedia

Notes

rs2297508 is one of several SNPs associated with the SREBF1 gene that show a modest association with type-2 diabetes. A study of ~2,000 Caucasian patients (and 10,000+ controls) led to an odds ratio of 1.17 (CI: 1.05-1.30, p=0.003) for the minor (risk) allele, rs2297508(C). A meta-analysis included other published studies concluded the odds ratio was 1.08 (CI: 1.03-1.14, p=0.001). type-2 diabetes rs2297508(C) and rs11868035(C)

Source and license

Adapted from rs2297508 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.