rs7659604

A SNP on chromosome 4. Its most notable genotype is C;C: 1.1x risk of type II diabetes

Gene
None listed
Location
Chr 4121,744,359 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
45%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad1.1x risk of type II diabetesTypical · 0.030% of people
  2. C;TBad1.4x risk of type II diabetesTypical · 0.043% of people
  3. T;TGoodnormalTypical · 0.026% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 30% C;T 43% T;T 26%
  • European ancestry (Utah)C;C 31% C;T 51% T;T 18%
  • Han Chinese (Beijing)C;C 41% C;T 47% T;T 12%
  • Japanese (Tokyo)C;C 51% C;T 38% T;T 12%
  • Yoruba (Nigeria)C;C 10% C;T 38% T;T 52%
  • African ancestry (Southwest US)C;C 7% C;T 50% T;T 43%
  • Chinese (Denver)C;C 39% C;T 45% T;T 16%
  • Gujarati IndianC;C 39% C;T 31% T;T 29%
  • Luhya (Kenya)C;C 12% C;T 42% T;T 46%
  • Mexican ancestry (Los Angeles)C;C 66% C;T 29% T;T 5%
  • Maasai (Kenya)C;C 12% C;T 47% T;T 41%
  • TuscanC;C 25% C;T 61% T;T 15%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs7659604 has been reported in a large study to be associated with type-2 diabetes. The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.35 (CI 1.19-1.54), and for homozygotes, 1.09 (CI 0.91-1.30).

C;T

1.4x risk of type-2 diabetes

Source and license

Adapted from rs7659604 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.