rs9930506

A SNP in the FTO gene on chromosome 16. Its most notable genotype is A;A: normal

Gene
FTO
Location
Chr 1653,796,553 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
30%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormalTypical · 0.054% of people
  2. A;GNot ratedNo summary available.Typical · 0.038% of people
  3. G;GNot ratedNo summary available.Typical · 0.08% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 54% A;G 38% G;G 8%
  • European ancestry (Utah)A;A 25% A;G 54% G;G 21%
  • Han Chinese (Beijing)A;A 64% A;G 31% G;G 5%
  • Japanese (Tokyo)A;A 58% A;G 39% G;G 4%
  • Yoruba (Nigeria)A;A 65% A;G 31% G;G 3%
  • African ancestry (Southwest US)A;A 63% A;G 36% G;G 2%
  • Chinese (Denver)A;A 63% A;G 30% G;G 6%
  • Gujarati IndianA;A 42% A;G 48% G;G 11%
  • Luhya (Kenya)A;A 73% A;G 25% G;G 2%
  • Mexican ancestry (Los Angeles)A;A 55% A;G 43% G;G 2%
  • Maasai (Kenya)A;A 56% A;G 42% G;G 1%
  • TuscanA;A 32% A;G 43% G;G 26%

Conditions, medicines and genes

Other FTO SNPs

All FTO SNPs

Notes

From SNPedia

Show notes, about 460 words

This snp influences obesity however * the most strongly linked neighboring snp is rs9939609 * some evidence suggests rs1421085 may be the true causative snp This plos genetics paper reports rs9930506 showed the strongest association with BMI (p = 8.6 *10-7), hip circumference (p = 3.4 * 10-8) and weight (p = 9.1 * 10-7). homozygotes for the rare "G" allele were were 1.3 BMI units heavier than homozygotes for the common "A" allele. This SNP did not show any association with obesity, type-2 diabetes or any other related traits in a study of 3,210 Chinese subjects. Furthermore, the minor allele frequency was much lower in Chinese populations compared to populations of European descent. rs9930506 (A;A) showed decreased levels of methylated PPARGC1A in comparison with AG + GG genotypes, suggesting a potential role of promoter PPARGC1A methylation in metabolic programming. Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. Variations in the FTO gene are associated with severe obesity in the Japanese. Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population. FTO variants are associated with obesity in the Chinese and Malay populations in Singapore. Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Using new tools to define the genetic underpinnings of risky traits associated with coronary artery disease: the SardiNIA study. Tests for candidate-gene interaction for longitudinal quantitative traits measured in a large cohort. Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study. Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia. Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study. FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome. Influence of genomic variation in FTO at 16q12.2, MC4R at 18q22 and NRXN3 at 14q31 genes on breast cancer risk.

A;G

This is the genotype of User:Watson

G;G

People with this genotype were 1.3 BMI units heavier than people with rs9930506(A;A) (paper)

Source and license

Adapted from rs9930506 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.