rs3750425

A SNP in the TRPM6 gene on chromosome 9. Its most notable genotype is C;C: common in clinvar

Gene
TRPM6
Location
Chr 974,762,494 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
14%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommon in clinvarTypical · 0.071% of people

On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 71%
  • European ancestry (Utah)C;C 88%
  • Han Chinese (Beijing)C;C 72%
  • Japanese (Tokyo)C;C 80%
  • Yoruba (Nigeria)C;C 53%
  • African ancestry (Southwest US)C;C 61%
  • Chinese (Denver)C;C 72%
  • Gujarati IndianC;C 65%
  • Luhya (Kenya)C;C 61%
  • Mexican ancestry (Los Angeles)C;C 88%
  • Maasai (Kenya)C;C 57%
  • TuscanC;C 85%

Conditions, medicines and genes

Other TRPM6 SNPs

All TRPM6 SNPs

Notes

From SNPedia

Notes

4.9x risk of type-2 diabetes among women carriers of both the rare alleles at rs3750425 and rs2274924 when their magnesium intake was lower than 250 mg per day.

Source and license

Adapted from rs3750425 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.