rs1137101
A SNP in the LEPR gene on chromosome 1. Its most notable genotype is G;G: Slight increase in obesity and T2DM risk
- Gene
- LEPR
- Location
- Chr 165,592,830 (GRCh38)
- Highest magnitude
- 1.5Minor
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 41%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AGoodcommon in clinvar
- A;GBadSlight increase in obesity and T2DM risk
- G;GMost notableBadSlight increase in obesity and T2DM risk
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 18% A;G 45% G;G 37%
- European ancestry (Utah)A;A 26% A;G 54% G;G 21%
- Han Chinese (Beijing)A;A 2% A;G 18% G;G 80%
- Japanese (Tokyo)A;A <1% A;G 34% G;G 65%
- Yoruba (Nigeria)A;A 11% A;G 58% G;G 31%
- African ancestry (Southwest US)A;A 20% A;G 36% G;G 45%
- Chinese (Denver)A;A 0% A;G 28% G;G 72%
- Gujarati IndianA;A 26% A;G 54% G;G 20%
- Luhya (Kenya)A;A 32% A;G 47% G;G 21%
- Mexican ancestry (Los Angeles)A;A 25% A;G 56% G;G 19%
- Maasai (Kenya)A;A 24% A;G 59% G;G 17%
- TuscanA;A 36% A;G 51% G;G 13%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 140 words
rs1137101, also known as c.668A>G, p.Gln223Arg, Arg223Gln, R223Q and Q223R, represents a very common variant in the LEPR gene on chromosome 1. The rs1137101(A) allele encodes the Gln/Q codon; the (G) allele encodes the Arg/R allele. The most common allele varies somewhat depending on the population. A 2016 meta-analysis of 11 studies (~5000 cases in total) concludes that the rs1137101(G) allele is significantly associated with type-2 diabetes, with an odds ratio of about 1.2 - 1.8 (depending on the inheritance model). obesity Q223R rs1137101 may be associated with obesity in women with a psychotic disorder treated with atypical antipsychotic drugs Gln223Arg polymorphism could be considered a disease susceptibility modulating factor both in ischemic heart disease or dilated cardiomyopathy patients.
A;G
see discussion at rs1137101
G;G
see discussion at rs1137101
Source and license
Adapted from rs1137101 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.