rs8179183

A SNP in the LEPR gene on chromosome 1. Its most notable genotype is C;G: less likely to gain weight if taking risperidone

Gene
LEPR
Location
Chr 165,610,269 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
15%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot ratednormalTypical · 0.0<1% of people
  2. C;GMost notableGoodless likely to gain weight if taking risperidoneMinor · 1.019% of people
  3. G;GGoodless likely to gain weight if taking risperidoneMinor · 1.081% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C <1% C;G 19% G;G 81%
  • European ancestry (Utah)C;C 2% C;G 17% G;G 82%
  • Han Chinese (Beijing)C;C 0% C;G 4% G;G 96%
  • Japanese (Tokyo)C;C 0% C;G 25% G;G 75%
  • Yoruba (Nigeria)C;C 0% C;G 29% G;G 71%

Conditions, medicines and genes

Other LEPR SNPs

All LEPR SNPs

Notes

From SNPedia

Notes

rs8179183 is a SNP in the leptin receptor LEPR gene. In a study of 101 mostly Caucasian patients prescribed the atypical antipsychotic risperidone, carriers of a rs8179183(G) allele were less likely to gain significant weight compared to rs8179183(C;C) carriers, as assessed by physiogenomic analysis of corresponding weight profiles. Two other SNPs, rs6837793 and rs705381, were also significantly associated with weight profiles in these patients.

Source and license

Adapted from rs8179183 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.