rs1137100

A SNP in the LEPR gene on chromosome 1. Its most notable genotype is A;A: common in clinvar

Gene
LEPR
Location
Chr 165,570,758 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
39%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodcommon in clinvarTypical · 0.050% of people

On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 50%
  • European ancestry (Utah)A;A 50%
  • Han Chinese (Beijing)A;A 2%
  • Japanese (Tokyo)A;A 4%
  • Yoruba (Nigeria)A;A 71%
  • African ancestry (Southwest US)A;A 66%
  • Chinese (Denver)A;A <1%
  • Gujarati IndianA;A 75%
  • Luhya (Kenya)A;A 88%
  • Mexican ancestry (Los Angeles)A;A 50%
  • Maasai (Kenya)A;A 82%
  • TuscanA;A 68%

Conditions, medicines and genes

Other LEPR SNPs

All LEPR SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

rs1137100 is a nonsynonymous coding SNP in exon 4 of the leptin receptor LEPR gene. It has been reported to affect glucose tolerance and insulin response, and it is also one of five SNPs reported to be useful in a SNP set defining the risk of dying from prostate cancer among patients with the disease; see gs242 and gs243.

Source and license

Adapted from rs1137100 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.