rs1528133

A SNP in the RIC3 gene on chromosome 11. Its most notable genotype is T;T: normal risk

Gene
RIC3
Location
Chr 118,128,206 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
9%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodnormal riskTypical · 0.081% of people
  2. G;TNot ratedhigher body mass indexTypical · 0.018% of people
  3. G;GNot ratedhigher body mass indexTypical · 0.01% of people
  4. A;ANot ratedNo summary available.Typical · 0.00% of people

SNPedia records rs1528133 on the minus strand: (A;A), (A;C), (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 81% G;T 18% G;G 1% A;A 0%
  • European ancestry (Utah)T;T 89% G;T 11% G;G 0% A;A 0%
  • Han Chinese (Beijing)T;T 88% G;T 12% G;G 0% A;A 0%
  • Japanese (Tokyo)T;T 87% G;T 12% G;G 2% A;A 0%
  • Yoruba (Nigeria)T;T 74% G;T 23% G;G 3% A;A 0%
  • African ancestry (Southwest US)T;T 68% G;T 28% G;G 4% A;A 0%
  • Chinese (Denver)T;T 92% G;T 8% G;G 0% A;A 0%
  • Gujarati IndianT;T 76% G;T 22% G;G 2% A;A 0%
  • Luhya (Kenya)T;T 71% G;T 26% G;G 3% A;A 0%
  • Mexican ancestry (Los Angeles)T;T 79% G;T 21% G;G 0% A;A 0%
  • Maasai (Kenya)T;T 81% G;T 18% G;G <1% A;A 0%
  • TuscanT;T 85% G;T 15% G;G 0% A;A 0%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 150 words

rs1528133, a SNP in the TUB gene, was found in a study of 492 unrelated type-2 diabetes patients to have a significant effect on body mass index and thus obesity (1.54 kg/m(2), p= 0.006). When two populations were combined, totaling ~1200 patients, the risk allele (rs1528133(C) averaged an increase of 0.54 kg/m2 (CI: &#226;&#8364;&#8220;0.19-1.26). Two additional TUB SNPs, rs2272382, and rs2272383, mapping to the 3' end of the gene showed similar associations and were in linkage disequilibrium with rs1528133. A follow-up study of 1,680 middle-aged Dutch women found that this allele, rs1528133(C), was significantly associated with increased weight (+1.88 kg, p=0.022) and body mass index (+0.56 units, p= 0.05). rs1528133(C) carriers were also associated with an increased glycemic load of 1.85 units compared with non-carriers. TUB is a candidate gene for late-onset obesity in women.

Source and license

Adapted from rs1528133 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.