rs7923837

A SNP on chromosome 10. Its most notable genotype is G;G: 3.2x risk for T2D

Gene
None listed
Location
Chr 1092,722,160 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
43%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodnormal risk for T2DTypical · 0.024% of people
  2. A;GBad1.6x risk for T2DMinor · 1.931% of people
  3. G;GMost notableBad3.2x risk for T2DWorth knowing · 2.045% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 24% A;G 31% G;G 45%
  • European ancestry (Utah)A;A 16% A;G 42% G;G 43%
  • Han Chinese (Beijing)A;A 60% A;G 33% G;G 7%
  • Japanese (Tokyo)A;A 64% A;G 32% G;G 4%
  • Yoruba (Nigeria)A;A 0% A;G 0% G;G 100%
  • African ancestry (Southwest US)A;A 0% A;G 21% G;G 79%
  • Chinese (Denver)A;A 63% A;G 32% G;G 5%
  • Gujarati IndianA;A 34% A;G 56% G;G 10%
  • Luhya (Kenya)A;A 0% A;G 16% G;G 85%
  • Mexican ancestry (Los Angeles)A;A 12% A;G 50% G;G 38%
  • Maasai (Kenya)A;A 3% A;G 21% G;G 76%
  • TuscanA;A 16% A;G 40% G;G 44%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 200 words

rs7923837 is a SNP of the HHEX homeobox gene. In several studies, it has been associated with risk for type-2 diabetes (T2D). In a study of 500 unrelated Caucasian T2D patients, the rs7923837(G) allele was overrepresented; the odds ratio was 1.57 (CI: 1.08-2.27, p=0.017). In this population, the population attributable risk for this allele was estimated to be 33%. In a study of ~400 Japanese T2D patients, rs7923837(G) was also associated with type-2 diabetes (odds ratio 1.66, CI: 1.28-2.15, p=0.00014). Heterozygous and homozygous carriers of the risk allele had odds ratios of 1.57 (95% CI 1.15-2.16, p=0.0050) and 3.16 (95% CI 1.40-7.16, p=0.0038) relative to non-carriers. rs7923837 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.27 (CI: 1.13-1.43, p = 1.0 x 10e-4) This SNP was confirmed to be associated with type-2 diabetes in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese). rs7923837 and rs1111875 were significantly associated with decreased insulin secretion and lower insulinogenic index in a study of 420 Germans in the MESYBEOP cohort.

Source and license

Adapted from rs7923837 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.