rs2077119

A SNP in the AHSG gene on chromosome 3. Its most notable genotype is G;G: 0.91x decreased risk for T2D

Gene
AHSG
Location
Chr 3186,612,673 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
38%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableNot rated0.91x decreased risk for T2DTypical · 0.021% of people
  2. G;TNot rated0.91x decreased risk for T2DTypical · 0.037% of people
  3. T;TNot rated1x normal riskTypical · 0.042% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 21% G;T 37% T;T 42%
  • European ancestry (Utah)G;G 20% G;T 48% T;T 32%
  • Han Chinese (Beijing)G;G 36% G;T 47% T;T 18%
  • Japanese (Tokyo)G;G 27% G;T 50% T;T 23%
  • Yoruba (Nigeria)G;G 0% G;T 3% T;T 97%

Conditions, medicines and genes

Other AHSG SNPs

All AHSG SNPs

Notes

From SNPedia

Notes

rs2077119, also known as -469T/G, is a SNP in the alpha-2-HS-glycoprotein AHSG gene. In a study of ~3,800 Danish type-2 diabetes patients, pooled with a previous study, the minor rs2077119(G) allele showed a slight protective effect, with an odds ratio of 0.91 (CI: 0.84-0.99, p=0.007).

Source and license

Adapted from rs2077119 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.