rs1495377

A SNP on chromosome 12. Its most notable genotype is G;G: normal

Gene
None listed
Location
Chr 1271,183,321 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
35%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodnormalTypical · 0.011% of people
  2. C;GBad1.3x risk type-2 diabetesTypical · 0.041% of people
  3. C;CBad1.5x risk type-2 diabetesTypical · 0.048% of people

SNPedia records rs1495377 on the minus strand: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 11% C;G 41% C;C 48%
  • European ancestry (Utah)G;G 20% C;G 58% C;C 23%
  • Han Chinese (Beijing)G;G 8% C;G 34% C;C 59%
  • Japanese (Tokyo)G;G 12% C;G 43% C;C 45%
  • Yoruba (Nigeria)G;G 1% C;G 27% C;C 72%
  • African ancestry (Southwest US)G;G 5% C;G 46% C;C 49%
  • Chinese (Denver)G;G 9% C;G 38% C;C 52%
  • Gujarati IndianG;G 17% C;G 48% C;C 35%
  • Luhya (Kenya)G;G 4% C;G 35% C;C 62%
  • Mexican ancestry (Los Angeles)G;G 5% C;G 35% C;C 60%
  • Maasai (Kenya)G;G 8% C;G 43% C;C 49%
  • TuscanG;G 35% C;G 48% C;C 18%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs1495377 has been reported in a large study to be associated with type-2 diabetes. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.28 (CI 1.11-1.49), and for homozygotes, 1.51 (CI 1.28-1.78). Note: orientation of this SNP is presumed correct but should be confirmed

Source and license

Adapted from rs1495377 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.