rs2930291

A SNP in the CCDC33 gene on chromosome 15. Its most notable genotype is G;G: 1.5x risk

Gene
CCDC33
Location
Chr 1574,312,493 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
46%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBad1.5x riskTypical · 0.016% of people
  2. A;GNot rated1.3x riskTypical · 0.043% of people
  3. A;ANot ratednormalTypical · 0.040% of people

SNPedia records rs2930291 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 16% A;G 43% A;A 40%
  • European ancestry (Utah)G;G 38% A;G 52% A;A 11%
  • Han Chinese (Beijing)G;G 8% A;G 37% A;A 56%
  • Japanese (Tokyo)G;G 6% A;G 39% A;A 55%
  • Yoruba (Nigeria)G;G 9% A;G 41% A;A 50%
  • African ancestry (Southwest US)G;G 12% A;G 51% A;A 37%
  • Chinese (Denver)G;G 6% A;G 41% A;A 53%
  • Gujarati IndianG;G 19% A;G 43% A;A 39%
  • Luhya (Kenya)G;G 16% A;G 46% A;A 38%
  • Mexican ancestry (Los Angeles)G;G 29% A;G 43% A;A 28%
  • Maasai (Kenya)G;G 6% A;G 38% A;A 56%
  • TuscanG;G 33% A;G 45% A;A 22%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs2930291 has been reported in a large study to be associated with type-2 diabetes. The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.25 (CI 1.04-1.51), and for homozygotes, 1.50 (CI 1.24-1.82).

Source and license

Adapted from rs2930291 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.