rs10811661

A SNP on chromosome 9. Its most notable genotype is T;T: 1.2x increased risk for type-2 diabetes

Gene
None listed
Location
Chr 922,134,095 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
21%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodnormalTypical · 0.07% of people
  2. C;TBad1.2x increased risk for type-2 diabetesWorth knowing · 2.027% of people
  3. T;TMost notableBad1.2x increased risk for type-2 diabetesWorth knowing · 2.166% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 7% C;T 27% T;T 66%
  • European ancestry (Utah)C;C 5% C;T 29% T;T 66%
  • Han Chinese (Beijing)C;C 23% C;T 44% T;T 34%
  • Japanese (Tokyo)C;C 20% C;T 57% T;T 23%
  • Yoruba (Nigeria)C;C 0% C;T 5% T;T 95%
  • African ancestry (Southwest US)C;C 0% C;T 18% T;T 83%
  • Chinese (Denver)C;C 20% C;T 52% T;T 28%
  • Gujarati IndianC;C 0% C;T 19% T;T 81%
  • Luhya (Kenya)C;C 2% C;T 8% T;T 90%
  • Mexican ancestry (Los Angeles)C;C 2% C;T 16% T;T 83%
  • Maasai (Kenya)C;C 3% C;T 17% T;T 80%
  • TuscanC;C 5% C;T 28% T;T 68%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 220 words

rs10811661 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.27 (CI: 1.15-1.40, p = 1.9 x 10e-6) rs10811661 is mentioned in part 2 of a series significantly associated with type-2 diabetes p = 0.0024; in 1,630 Japanese subjects with type-2 diabetes and in 1,064 controls 1,638 type 2 diabetes patients and 1,858 controls *rs10811661 in the vicinity of CDKN2B (OR 1.20, 95% CI: 1.06-1.37, p = 0.004) T2D and normal glucose tolerant (NGT) individuals. (3,295 T2D and 3,595 NGT), strong associations with T2D were found for *CDKAL1 (OR(rs7756992) = 1.30[1.19-1.42], P = 2.3x10(-9)) *CDKN2A/2B (OR(rs10811661) = 0.74[0.66-0.82], P = 3.5x10(-8)) *IGFBP2 (OR(rs1470579) = 1.17[1.07-1.27], P = 0.0003) SNPs. T2D risk increased strongly when risk alleles, including the previously discovered T2D-associated TCF7L2 rs7903146 SNP, were combined (8.68-fold for the 14% of French individuals carrying 18 to 30 risk alleles with an allelic OR of 1.24) Association between [r[s10811661]] and type-2 diabetes was replicated in a French Europid population, with an odds ratio of 1.43 (CI: 1.24-1.64, p = 3.8 x 10e-7). This SNP was confirmed to be associated with type-2 diabetes in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).

Source and license

Adapted from rs10811661 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.