rs367643250

A SNP in the DYRK1B gene on chromosome 19. Its most notable genotype is A;G: causative for obesity, coronary artery disease, type-2 diabetes?

Gene
DYRK1B
Location
Chr 1939,830,443 (GRCh38)
Highest magnitude
4.0Very important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;GMost notableBadcausative for obesity, coronary artery disease, type-2 diabetes?Very important · 4.0
  2. G;GGoodcommonTypical · 0.0

On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs367643250, aka R102C, is a SNP in the DYRK1B gene on chromosome 19. A study of three large families with coinheritance of early-onset coronary artery disease, central obesity, hypertension, and type-2 diabetes led to the conclusion that the responsible mutation was a C>T change (on the reverse strand) for this SNP, leading to a missense change from an arginine (R) at amino acid position 102 to a cysteine (C). On the forward strand represented by rs367643250 this means a change from a G>A.

A;G

Heterozygotes for this SNP are reported to have metabolic syndrome based on a study of three families.

Source and license

Adapted from rs367643250 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.