rs1801282
A SNP in the PPARG gene on chromosome 3. Its most notable genotype is C;G: Unconfirmed higher risk of cardiovascular disease with high saturated fat diet
- Gene
- PPARG
- Location
- Chr 312,351,626 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 7%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodnormal fat metabolism; common in clinvar
- C;GMost notableBadUnconfirmed higher risk of cardiovascular disease with high saturated fat diet
- G;GBadUnconfirmed higher risk of cardiovascular disease with high saturated fat diet
On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 10 HapMap populations.
- AverageC;C 90% C;G 9% G;G <1%
- European ancestry (Utah)C;C 82% C;G 16% G;G 2%
- Han Chinese (Beijing)C;C 89% C;G 10% G;G <1%
- Japanese (Tokyo)C;C 95% C;G 5% G;G 0%
- Yoruba (Nigeria)C;C 100% C;G 0% G;G 0%
- African ancestry (Southwest US)C;C 95% C;G 5% G;G 0%
- Chinese (Denver)C;C 94% C;G 6% G;G <1%
- Gujarati IndianC;C 83% C;G 15% G;G 2%
- Mexican ancestry (Los Angeles)C;C 79% C;G 19% G;G 2%
- Maasai (Kenya)C;C 97% C;G 3% G;G 0%
- TuscanC;C 86% C;G 14% G;G 0%
Related
Conditions, medicines and genes
Other PPARG SNPs
- rs17036170A;AElevated risk for drug induced liver injury with diclofenacWorth knowing
- rs1899951C;CNo summary available.Typical
- rs2197423G;GNo summary available.Typical
- rs3856806C;Ccommon in clinvarTypical
- rs6802898C;CNo summary available.Typical
- rs13306747C;Ccommon in clinvarTypical
- rs17036314C;Crisk of progressing from IGT to T2D; reduced by exerciseTypical
- rs17241090C;CNo summary available.Typical
Genosets
- Gs197Increased type-2 diabetes riskWorth knowing
- Gs284any diet works for youWorth knowing
- Gs285claimed to lose 2.5x as much weight on a low fat dietWorth knowing
- Gs283claimed to lose 2.5x as much weight on a lower carb dietWorth knowing
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Show notes, about 230 words
rs1801282, also known as Pro12Ala, is a common SNP in the peroxisome proliferator-activated receptor PPARG gene. The more common (C) allele (in dbSNP orientation) encodes the 'Pro' amino acid at this SNP position. rs1801282 has been reported to be associated with metabolic syndrome, but other studies have not been able to replicate any strong or significant effect. The association between type-2 diabetes and SNP rs1801282 is mentioned as being replicated in rs1801282 and risk of cognitive decline in elders? Maybe with diabetes. A ten-year study of 679 male patients with symptomatic coronary artery disease found that rs1801282(G) carriers had a much lower (10 year) cardiovascular risk, with the hazard ratio estimated to be 0.10 (CI: 0.01-0.70, p = 0.02) for ischemic heart disease and 0.24 for vascular death (CI: 0.08-0.74, p = 0.013) per copy of the allele. 23andMe blog carriers could be informed that they really need to watch out for high fat in their diets {{PMID Auto |PMID=19720797 |Title=Impact of The PPAR-{gamma}2 Pro12Ala polymorphism and ACE inhibitor therapy on new-onset microalbuminuria in type 2 Diabetes: evidence from Benedict |OA=1 }} {{PMID Auto |PMID=20179158 |Title=The Association Between the Peroxisome Proliferator-Activated Receptor-{gamma}2 (PPARG2) Pro12Ala Gene Variant and Type 2 Diabetes Mellitus: A HuGE Review and Meta-Analysis |OA=1 }} Response to Diet and Exercise
Source and license
Adapted from rs1801282 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.