rs17036170

A SNP in the PPARG gene on chromosome 3. Its most notable genotype is A;A: Elevated risk for drug induced liver injury with diclofenac

Gene
PPARG
Location
Chr 312,288,912 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
<1%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadElevated risk for drug induced liver injury with diclofenacWorth knowing · 2.04% of people
  2. A;GBadIncreased risk of drug induced liver injury with diclofenacMinor · 1.996% of people
  3. G;GGoodcommon/normalTypical · 0.00% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 4% A;G 96% G;G 0%
  • European ancestry (Utah)A;A <1% A;G 99% G;G 0%
  • African ancestry (Southwest US)A;A 2% A;G 98% G;G 0%
  • Mexican ancestry (Los Angeles)A;A 6% A;G 94% G;G 0%
  • TuscanA;A 7% A;G 93% G;G 0%

Other PPARG SNPs

All PPARG SNPs

Notes

From SNPedia

Notes

A;A

This uncommon risk allele A was found in a GWAS to be associated with drug induced liver injury with diclofenac. OR = 11.3 (4.9–25.9) Replicability is uncertain, but individuals with this genotype should be aware of the potential of increased risk. The odds ratio above is probably for heterozygotes, and it is not clear if the homozygous AA is worse, if in fact the risk can be replicated.

A;G

This uncommon risk allele A was found in a GWAS to be associated with drug induced liver injury with diclofenac. OR = 11.3 (4.9–25.9) Replicability is uncertain, but individuals with this genotype should be aware of the potential of increased risk.

Source and license

Adapted from rs17036170 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.